Repeated Administrations of Rituximab along with Steroids and Immunosuppressive Agents in Refractory Steroid-resistant Nephrotic Syndrome.
نویسندگان
چکیده
BACKGROUND A recent randomized control trial in children with steroid-resistant nephrotic syndrome revealed that two doses of rituximab did not reduce proteinuria. CASE CHARACTERISTICS A 14-month-old boy developed refractory steroid-resistant nephrotic syndrome due to focal segmental glomerulosclerosis. OBSERVATION The patient achieved complete remission 11 months after disease onset following eight doses of rituximab combined with steroids and cyclosporine. MESSAGE Long-lasting B cell depletion with repeated rituximab administrations may be required to achieve complete remission in patients with steroid-resistant nephrotic syndrome and massive proteinuria.
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عنوان ژورنال:
- Indian pediatrics
دوره 54 1 شماره
صفحات -
تاریخ انتشار 2017